This has been mentioned as possibly one of the best stoner comedies for both those who like to toke and those who don't, and as a member of the latter, I have to agree.
However, my local friends can now all flagellate themselves for neglecting to mention that there was not only a sequel, but one that touches on something near, dear, and rantable to all of us:
Harold and Kumar Escape from Gitmo
I am not making this up. Navigation Officer Sulu and House's new whipping boy are going to Gitmo, and coming back, with Neil Patrick Harris along for the ride.